phenobarbital will lower the extent or result of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Sturdy or moderate CYP3A4 inducers might increase price of diazepam elimination; for that reason, efficacy of diazepam might be lessened.Barbiturates are metabolized principally from the hepatic microsomal en